Peter Chung

Andy Jones

Yoshiaki Kawajiri

Takeshi Koike

Kevin Michael Richardson
Thadeus (segment "Final Flight of the Osiris") / Cop (segment "Kid's Story") / Agent #2 (segment "World Record") (voice)

Pamela Adlon
Jue (segment "Final Flight of the Osiris") / Manabu (segment "Beyond") (voice)

John Di Maggio
Crew Man (segment "Final Flight of the Osiris") / Kaiser (segment "Program") (voice)

Tom Kenny
Operator (segment "Final Flight of the Osiris") (voice)

Dane A. Davis
01 Versatran Spokesman (segment "The Second Renaissance, Part II") (voice) (as Dane Davis)

Debi Derryberry
Kid (segment "The Second Renaissance, Part II") (voice)

Jill Talley
Mother (segments "The Second Renaissance, Parts I&II") / Townsperson (segment "Beyond") (voice)

Dwight Schultz
Townspeople / Policeman / Exterminators (segment "Beyond") / Nonaka (segment "Matriculated") (segments "The Second Renaissance, Part I & II") (voice)

John DeMita
Teacher (segment "Kid's Story") (voice)

Hedy Burress
Cis (segment "Program") / Yoko (segment "Beyond") (voice)

Phil LaMarr
Duo (segment "Program") (voice)

Victor Williams
Dan (segment "World Record") (voice)

Tress MacNeille
Housewife / Kenny (segment "Beyond") (voice)

Kath Soucie
Pudgy / Masa / Sara (segment "Beyond") (voice)

Jack Fletcher
Townsperson (segment "Beyond") / Sandro (segment "Matriculated") (voice)

Terrence 'T.C.' Carson
Clarence (segment "A Detective Story") (voice) (as T.C. Carson)

Eric Aten
Noah, Tyler